Lifeblood: The Thrombosis Charity
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 Source: thrombosis-charity.org.uk |
| Clinical Resource: Various |
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| Last Checked: 02/07/14 | Link Error: Report It |
For over a decade, we have been involved in projects to improve the use of prophylaxis for deep vein thrombosis (DVT) in Massachusetts hospitals. We want to share the lessons of this experience. The tools provided in this manual will help you to create a structured quality improvement program that can assist physicians and hospital quality assurance managers in evaluating and improving the use of DVT prophylaxis. Implementation of a system-wide process for preventing DVT will also help your hospital meet the JCAHO requirement for quality improvement activities.
| Source: outcomes-umassmed.org |
| Clinical Resource: Various |
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| Last Checked: 02/07/14 | Link Error: Report It |
The management of venous thromboembolism in pregnancy is challenging, as many diagnostic tests are less accurate in pregnant than in non-pregnant patients, and some of the radiological procedures are potentially hazardous to the fetus. In addition, anticoagulant treatment with coumarins can cause embryopathy. The authors recommend strategies for women at risk of deep venous thrombosis or pulmonary thromboembolism during pregnancy and outline appropriate investigations and treatment.
| Source: eu.wiley.com |
| Clinical Resource: Journal Article |
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| Last Checked: 07/05/14 | Link Error: Report It |
This article reviews the epidemiology, clinical features, diagnostic process, and treatment of pulmonary embolism.
| Source: racgp.org.au |
| Clinical Resource: Journal Article |
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| Last Checked: 02/07/14 | Link Error: Report It |
Objective testing for pulmonary embolism is necessary, because clinical assessment alone is unreliable and the consequences of misdiagnosis are serious. No single test has ideal properties (100% sensitivity and specificity, no risk, low cost).
| Source: europepmc.org |
| Clinical Resource: Journal Article |
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| Last Checked: 07/04/14 | Link Error: Report It |
This bulletin looks at the appropriate prescribing and monitoring of LMWH for the treatment and prophylaxis of VTE in adults.
| Source: wemerec.org |
| Clinical Resource: Medicines Resource Centre Bulletin |
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| Last Checked: 16/11/17 | Link Error: Report It |
Routine laboratory monitoring is not routinely required, with the exception of patients with renal insuffciency. However, since LMWHs inhibit factor Xa more than thrombin, assays for anti-factor Xa activity, rather than the aPTT, must be used for monitoring.
| Source: pathology.vcu.edu |
| Clinical Resource: Educational Resource |
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| Last Checked: 17/02/14 | Link Error: Report It |
There have been a number of medication incidents reported recently involving the use of enoxaparin in patients with severe renal impairment (creatinine clearance less than 30ml/min) who, as a result of treatment have suffered a haemorrhage.
| Source: medicinesgovernance.hscni.net |
| Clinical Resource: Memo |
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| Last Checked: 31/03/14 | Link Error: Report It |
Heparin therapy requires rigorous laboratory monitoring with the activated partial thromboplastim time (aPPT), since its bioavailability is variably affected by binding to plasma and cellular proteins. Unfractionated heparin is gradually being replaced by low molecular weight heparin, which has a longer half-life and more predictable bioavailability.
| Source: pathology.vcu.edu |
| Clinical Resource: Educational Resource |
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| Last Checked: 17/02/14 | Link Error: Report It |
Welcome to WarfarinDosing.org, a free Web site to help doctors and other clinicians begin warfarin therapy by estimating the therapeutic dose in patients new to warfarin. This site is supported by the Barnes-Jewish Hospital at Washington University Medical Center, the NIH, and donations. Estimates are based on clinical factors and (when available) genotypes of two genes: cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1).
Recommendations on this Web site are based on data from over 1000 patients.Once information is entered onto the next page, the initial estimate of therapeutic dose explains 53% of the variability in a warfarin dose. If you return to the Web site and enter an INR value after 3 and/or 4 warfarin doses, the dose refinement is even more accurate.
| Source: warfarindosing.org |
| Clinical Resource: Calculator |
| Register to Access Content: No |
| Last Checked: 17/02/14 | Link Error: Report It |
Crystalline warfarin sodium (Coumadin, Panwarfin, Sofarin, Coufarin, Athrombin-K) is the most widely used oral anticoagulant in the world. Warfarin interferes with the hepatic synthesis of the vitamin-K dependent coagulation factors by interfering with the vitamin K cycle. Laboratory monitoring of warfarin therapy is mandatory, since the agent has a relatively narrow therapeutic range.
| Source: pathology.vcu.edu |
| Clinical Resource: Educational Resource |
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| Last Checked: 17/02/14 | Link Error: Report It |
Full reversal of warfarin-induced coagulopathy is indicated in patients who do not require warfarin therapy. However, special consideration must be given to patients who require therapeutic anticoagulation in the event of a warfarin overdose. The purpose of this discussion is to review treatment guidelines for these patents.
| Source: utah.edu |
| Clinical Resource: Poison Control Centre Newsletter |
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| Last Checked: 02/07/14 | Link Error: Report It |
The drugs in this list are more usually associated with loss of INR control in patients already established on warfarin.
| Source: derbyhospitals.nhs.uk |
| Clinical Resource: List |
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| Last Checked: 02/07/14 | Link Error: Report It |
While anticoagulants are useful in many circumstances, their use during pregnancy increases the risk of hemorrhage and other adverse effects on the mother and the fetus. Treatment with anticoagulants during pregnancy must therefore be carefully considered, with judicious selection of the agent, and with reflection on the physiologic changes of pregnancy to ensure appropriate dosing. In this article, we review these issues.
| Source: mdedge.com |
| Clinical Resource: Journal Article |
| Register to Access Content: Yes - registration is FREE |
| Last Checked: 19/06/17 | Link Error: Report It |
This Medicines Q&A focuses on the potential risks of adverse effects associated with the administration of small volume IM injections to patients taking oral anticoagulants.
| Source: evidence.nhs.uk |
| Clinical Resource: Medicines Question and Answer |
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| Last Checked: 21/02/14 | Link Error: Report It |
| Source: bsg.org.uk |
| Clinical Resource: Guideline |
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| Last Checked: 13/03/14 | Link Error: Report It |
The Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy prepared this text.
| Source: asge.org |
| Clinical Resource: Guideline |
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| Last Checked: 02/07/14 | Link Error: Report It |
The purpose of this handbook is to help the many staff involved in providing and using blood products to make sure that the right blood product is given to the right patient at the right time.
| Source: transfusionguidelines.org.uk |
| Clinical Resource: Handbook |
| Register to Access Content: No |
| Last Checked: 07/04/14 | Link Error: Report It |
. This article aims to inform clinicians how to avoid these risks and how to make appropriate use of blood products.
| Source: rcpe.ac.uk |
| Clinical Resource: Journal Article |
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| Last Checked: 02/07/14 | Link Error: Report It |
Blood Conservation and Transfusion Avoidance Strategies in the Surgical Patient
These guidelines were prepared by the Department of Surgical Education, Orlando Regional Medical Center
| Source: surgicalcriticalcare.net |
| Clinical Resource: Guideline |
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| Last Checked: 21/08/15 | Link Error: Report It |
These draft care pathways have been developed on behalf of the London Regional Transfusion Committee with the aim of promoting a more standardised approach to the management of adult surgical patients refusing blood/blood component therapy (including JW patients).
| Source: transfusionguidelines.org.uk |
| Clinical Resource: Care Pathways |
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| Last Checked: 07/04/14 | Link Error: Report It |
The refreshed irontherapy.org website is a non-promotional, educational online resource which offers healthcare professionals, from a host of different therapeutic areas, the current and topical information they need to understand and manage iron deficiency effectively.
The development of the site content is guided and overseen by the Iron Therapy Steering Committee; a group of respected experts in iron therapy who play an integral role in the management and growth of the website. By submitting opinion pieces and participating in interviews and advisory boards, the Steering Committee influence the evolution of the site through strategic planning – and work with the Iron Therapy Secretariat to define editorial policy and content.
| Source: irontherapy.org |
| Clinical Resource: Various |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia
| Source: bsg.org.uk |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
British Columbia Clinical Practice Guideline for Iron Deficiency - Investigation and Management
| Source: gov.bc.ca |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 19/08/15 | Link Error: Report It |
CosmoFer.com offers information about iron deficiency anaemia and parenteral iron therapy.
| Source: cosmofer.com |
| Clinical Resource: Various |
| Register to Access Content: No |
| Last Checked: 22/02/17 | Link Error: Report It |
| Source: aintreerenalunit.nhs.uk/aintreerenal |
| Clinical Resource: Guideline |
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| Last Checked: 22/02/17 | Link Error: Report It |
The dose and dosage schedule for CosmoFer® must be determined individually based on a calculation of the patients total iron deficit; the total cumulative dose is determined by the patients haemoglobin (Hb) concentration (in g/dL) and their body weight (in kg).
| Source: sps.nhs.uk |
| Clinical Resource: Medicines Question and Answer |
| Register to Access Content: No |
| Last Checked: 22/09/16 | Link Error: Report It |
Iron Dextran Dosing calculator (iron deficit)
| Source: globalrph.com |
| Clinical Resource: Calculator |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
Parenteral iron preparations and iron deficiency anaemia
| Source: auspharmlist.net.au |
| Clinical Resource: Pharmacy E-Bulletin |
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| Last Checked: 22/02/17 | Link Error: Report It |
| Source: gov.bc.ca |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 19/08/15 | Link Error: Report It |
British Columbia Clinical Practice Guideline on Folate Deficiency - Investigation & Management
| Source: gov.bc.ca |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 19/08/15 | Link Error: Report It |
| Source: nice.org.uk |
| Clinical Resource: Guidance |
| Register to Access Content: No |
| Last Checked: 10/11/17 | Link Error: Report It |
| Source: european-renal-best-practice.org |
| Clinical Resource: Position Statement |
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| Last Checked: 02/07/14 | Link Error: Report It |
The association offers assistance to persons affected by the G6PD enzyme deficiency and their families, including helping with the protection of patients' social rights; informing and educating affected persons and the medical community on all aspects of the deficiency; helping organize petitions calling for government actions; and more.
Among the resources offered by the association are lists of contraindicated drugs (including some trade-names); an online forum; mailing lists; and a reserved area for medical professionals.
| Source: g6pd.org |
| Clinical Resource: Various |
| Register to Access Content: Yes - registration is FREE |
| Last Checked: 02/07/14 | Link Error: Report It |
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme deficiency that affects red blood cells (RBCs). It is highly prevalent in Africa, Asia, Oceania and Southern Europe, but can occur rarely in other individuals.
| Source: auspharmlist.net.au |
| Clinical Resource: Pharmacy E-Bulletin |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
| Source: iascnapa.org |
| Clinical Resource: Guidelines |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
| Source: nice.org.uk |
| Clinical Resource: Guidance |
| Register to Access Content: No |
| Last Checked: 10/11/17 | Link Error: Report It |
The mission of this site is to provide sickle cell patient and professional education, news, research updates and world wide sickle cell resources.
| Source: scinfo.org |
| Clinical Resource: Various |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
Key Inforbits
| Source: auburn.edu |
| Clinical Resource: Drug Information and Learning Resources Centre Bulletin |
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| Last Checked: 19/08/15 | Link Error: Report It |
Thalassaemia International Federation has a plethora of educational publications that provide concise, up-to date information on all aspects of thalassaemia, from prevention to clinical management, and cover almost all age groups.
TIF’s publications have been translated into many languages, in order to cover the needs of the medical/scientific community, the thalassaemia patients’/parents’ community and the general public.
| Source: thalassaemia.org.cy |
| Clinical Resource: Publications |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
Routine investigations in the management of thalassaemia
All thalassaemia patients (children and adults) should be assessed at least once a year at a specialist thalassaemia centre by a paediatrician or haematologist experienced in the treatment of thalassaemia. This is intended to give a detailed assessment of every aspect of the patient’s treatment and condition; to assess the patient’s progress and identify any areas where treatment could be improved. Additional investigations and measurements should be kept between the annual review checks, and recorded and discussed.
| Source: ukts.org |
| Clinical Resource: |
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| Last Checked: 02/07/14 | Link Error: Report It |
Guidelines for malaria prevention in travellers from the UK
These practical guidelines from the Public Health England Advisory Committee on Malaria Prevention for UK Travellers are updated and reissued annually. They are for use by healthcare workers who advise travellers but may also be of use to prospective travellers who wish to read about the options themselves.
| Source: gov.uk |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 29/09/15 | Link Error: Report It |
| Source: rcog.org.uk |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 19/08/15 | Link Error: Report It |
This document offers guidance for the management of both uncomplicated and complicated malaria in the UK.
| Source: britishinfection.org |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 20/08/15 | Link Error: Report It |
| Source: rcog.org.uk |
| Clinical Resource: Guideline |
| Register to Access Content: No |
| Last Checked: 19/08/15 | Link Error: Report It |
Malaria Topics
About Malaria
Diagnosis & Treatment
Malaria Worldwide
Travelers
Tools for Tomorrow
| Source: cdc.gov |
| Clinical Resource: Various |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
The Global malaria Programme (GMP) is responsible for malaria surveillance, monitoring and evaluation, policy and strategy formulation, technical assistance, and coordination of WHO's global efforts to fight malaria.
| Source: who.int |
| Clinical Resource: Various |
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| Last Checked: 02/07/14 | Link Error: Report It |
In this paper, we attempt to identify traveler types who are particularly at risk of malaria and to suggest evidence-based strategies for the various risk groups.
| Source: cmr.asm.org |
| Clinical Resource: Journal Article |
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| Last Checked: 02/07/14 | Link Error: Report It |
Chloroquine and mefloquine have superior safety profiles in pregnancy, though all antimalarials are effective for prophylaxis.
| Source: jfponline.com |
| Clinical Resource: Evidence Based Answer to Clinical Question |
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| Last Checked: 07/05/14 | Link Error: Report It |
This website attempts to provide the latest information on
| Source: ouhsc.edu |
| Clinical Resource: Various |
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| Last Checked: 02/07/14 | Link Error: Report It |
Although some drugs are used specifically for their antiplatelet effects, other commonly used drugs may affect platelet function causing prolongation of the bleeding time. The mechanisms behind the antiplatelet effects of drugs are described below. Drugs that cause thrombocytopenia are not discussed.
| Source: druginformation.co.nz |
| Clinical Resource: Drug Information Service Bulletin |
| Register to Access Content: No |
| Last Checked: 02/07/14 | Link Error: Report It |
The Disease Management Project is an online medical reference, designed to provide nationally established treatment guidelines for the most commonly seen diseases and conditions.
Chapter Section Links
| Source: clevelandclinicmeded.com |
| Clinical Resource: Medical Reference |
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| Last Checked: 02/07/14 | Link Error: Report It |
Drug-induced thrombocytopenia presents several diagnostic and management challenges. First, it can be difficult to definitively prove that a decrease in platelet count is drug-related, especially in the absence of sufficiently frequent platelet counts to allow for a clearly defined temporal relationship between drug administration and thrombocytopenia.
| Source: archivesofpathology.org |
| Clinical Resource: Journal Article |
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| Last Checked: 02/07/14 | Link Error: Report It |
What is HIT? What causes HIT? What is the clinical significance of HIT? How is HIT diagnosed? What are the laboratory features of Type I HIT? What are the laboratory features of Type II HIT? How is HIT treated?
| Source: pathology.vcu.edu |
| Clinical Resource: Frequently Asked Questions |
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| Last Checked: 02/07/14 | Link Error: Report It |
This article reviews the pathophysiology and provides updates presented in the recently revised American College of Chest Physicians practice guidelines with regard to management of HIT with and without thrombosis.
| Source: uspharmacist.com |
| Clinical Resource: Journal Article |
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| Last Checked: 02/07/14 | Link Error: Report It |
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